
Beyond Structural Angiography: The Emergence of Functional Coronary Angiography*
The evaluation of stable chest pain suspected to be cardiac in nature has traditionally involved the use of a screening noninvasive investigation, with invasive selective coronary angiography being the benchmark investigation.
Moreover, if the noninvasive investigation implicates the presence of myocardial ischemia (ie, new ischemic electrocardiographic [ECG] changes, perfusion defect, or regional wall abnormality) and the invasive coronary angiogram shows no evidence of obstructive coronary artery disease (CAD), then the noninvasive investigation is considered a false positive and the patient receives a diagnosis of “noncardiac chest pain.”