Tag: no obstructive coronary arteries

Research

Living with myocardial ischaemia and no obstructive coronary arteries: a...

Coronary artery disease is traditionally characterised by obstructive atherosclerosis. However, up to two in five people experience symptoms of myocardial ischaemia without obstructive coronary artery disease. This condition can be caused by a range of underlying pathologies including coronary endothelial dysfunction, microvascular remodelling, microvascular and epicardial spasm and vasomotor abnormalities.

A range of medical terms is used to describe distinct aspects of these conditions, including microvascular angina, coronary microvascular dysfunction, vasospastic angina, coronary vasospasms, coronary artery spasms, prinzmetal/variant angina and angina/ischaemia with no obstructive coronary arteries (ANOCA/INOCA). Women are disproportionately affected, particularly over the age of 40 years.

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Research

Novel therapy for ischaemia with no obstructive coronary arteries

Coronary vascular dysfunction causes microvascular angina and vasospastic angina, which are prevalent clinical endotypes of myocardial ischaemia with no obstructive coronary arteries (INOCA). INOCA impairs quality of life and confers an increased likelihood of cardiovascular events and health resource utilization.

Contemporary advances in non-invasive and invasive testing facilitate an accurate diagnosis and linked therapy. New guideline recommendations and patient advocacy are also relevant. Nonetheless, a lack of disease-modifying therapy for INOCA perpetuates the medical need.

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Around The World

Real Patient Stories

Sandra’s story

My story began in January 2010, while sitting at a traffic light returning to the office. I was working as a home health physical therapist. I began having chest pain out of nowhere. I got to my office and my boss, an RN, asked me if I was OK. I told her about the chest pain. By then it was starting to progress down my left arm. She took my blood pressure, normally 98/68. It was 140/90. She called my husband and told him to meet me at the ER. I drove myself there. They ran the normal tests and diagnosed me with costochondritis. Pain meds made the symptoms go away. The pain came back six times in the next 6 months. I asked for a cardiologist referral, but was denied, due to my age (39), lack of family history, and being in shape.

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Barbara’s story

I am a 62-year-old retired physician. My story began at age 47.

I was a very busy practicing OB/Gyn physician who was otherwise healthy.

I was on call at the hospital, and it was turning out to be one of the busiest days I had ever experienced as a physician. I was in a medical group that took call for 24 hours straight, most of the time working the entire 24 hours.

Halfway through that 24-hour call, I was in the operating room doing a C/Section on a patient. Halfway through the surgery I began to feel crushing chest pain.

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Charlotte’s story

While at work in September 2014, I lost vision of my left eye and had terrible feeling of “heat” all over the left side of my body.

The ER ophthalmologist directed me to cardiology for a vascular problem.

A week later, I could not walk 100 meters (325 feet) without crushing chest pain and shortness of breath.

I was no longer functional. Making my bed was all I could do in a whole day. I was no longer an active 54-year-old.

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