Tag: ischaemia with no obstructive coronary arteries

Research

Novel therapy for ischaemia with no obstructive coronary arteries

Coronary vascular dysfunction causes microvascular angina and vasospastic angina, which are prevalent clinical endotypes of myocardial ischaemia with no obstructive coronary arteries (INOCA). INOCA impairs quality of life and confers an increased likelihood of cardiovascular events and health resource utilization.

Contemporary advances in non-invasive and invasive testing facilitate an accurate diagnosis and linked therapy. New guideline recommendations and patient advocacy are also relevant. Nonetheless, a lack of disease-modifying therapy for INOCA perpetuates the medical need.

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Real Patient Stories

Jennifer’s story

Hello! My name is Jennifer, a 41-year-old mother of 5 and a nurse. My husband and I have been married nearly 15 years. Before I share my story, I’d like to share that I had never been on any medications other than Lexapro for mild depression and anxiety. I did not have heart problems or even high blood pressure. December 9, 2023, was the beginning of a life changing event leading to the diagnosis of Coronary Artery Spasm, also known as Prinzmetal Angina.

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Sinéad’s story

My first episode caught me completely off guard on a Sunday morning in 2014. I was an active, healthy 35-year-old mother of 3. It felt like what I imagined having a heart attack would feel like. After a minute or two it stopped as suddenly as it had started and I got out of bed to start my day, I had experienced palpitations before and brushed it off as a once off.

I had about 8 more episodes before lunch time and made a deal with myself that if it continued, I would call an ambulance. I was a busy mum and didn’t want to be ‘dramatic’! It resolved by 2 p.m.

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Lynn’s story

I had my first spasm when I was just a young child and continued for almost 50 years with no diagnosis. I always assumed everybody had flushing feelings throughout their body, and hot flashes accompanied by chest pain.

It wasn’t until I was walking my dogs with my sister, one day, and we were going up a steep incline and I couldn’t keep up. I asked her if she felt chest pains when she walked up hills. She looked at me like I was crazy and told me: No!

I then realized something might be wrong with me.

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